Certified Diabetes Educator Practice Exam 2026 - Free Practice Questions and Study Resource.

During the fasting state, blood glucose levels are primarily maintained through hepatic sources, particularly the liver's ability to release glucose into the bloodstream. This process is called glycogenolysis, where the liver breaks down glycogen stores into glucose. Additionally, gluconeogenesis occurs, wherein the liver synthesizes glucose from non-carbohydrate sources, such as amino acids and glycerol.

During fasting, the body needs to maintain adequate glucose levels for vital functions, particularly for the brain, which relies heavily on glucose as its primary energy source. Without dietary intake, the liver becomes the main regulator of blood glucose, ensuring that levels remain stable despite a lack of external sources.

Insulin secretion, increased muscle tissue glucose storage, and dietary intake all play roles in different metabolic contexts, such as after eating or during state when nourishing is occurring. However, in the fasting state, it is the liver’s actions that dominate in preventing hypoglycemia and ensuring a continuous supply of glucose.