Certified Diabetes Educator Practice Exam 2025 - Free Practice Questions and Study Resource.

SGLT2 inhibitors primarily work by decreasing glucose reabsorption in the kidneys. These medications inhibit the sodium-glucose co-transporter 2 (SGLT2), which is responsible for the reabsorption of glucose from the renal tubules back into the bloodstream. By blocking this transporter, SGLT2 inhibitors promote the excretion of glucose through urine, leading to lower blood glucose levels.

This mechanism not only helps manage blood sugar levels in individuals with type 2 diabetes but also contributes to weight loss and has favorable effects on cardiovascular health. Meanwhile, the other choices do not describe the primary action of SGLT2 inhibitors accurately: increasing glucose reabsorption contradicts the intended effect of the drug, enhancing insulin secretion pertains more to medications like sulfonylureas or GLP-1 agonists, and reducing gastric emptying is related to other diabetes medications, particularly those that affect gastrointestinal motility.